植物乳植杆菌
KLDS1.0386

This strain was first isolated in 2003

植物乳植杆菌KLDS1.0386(简称K0386),源自东北农业大学乳品学科教育部重点实验室。

是从乳制品中分离筛选出来的一株表现优异,具有中国自主知识产权的优质益生菌,研究成果获得国家重点

研发计划课题支持,已在国际知名期刊《Food Bioscience》上公开发表。

FEATURES

K0386主要作用

植物乳植杆菌KLDS1.0386共获得科研成果25项:论文22篇:SCI/中科院一区8篇,SCI/中科院二区3篇,SCI/中科院三区1篇,SCI/中科院四区1篇;EI8篇;核心期刊1篇;发明专利1项;教育部重点实验室研究报告2项。

  • 平衡神经递质:提升 5-HT、多巴胺、BDNF,舒缓冲动、提升专注力
  • 修护肠道稳态:修复肠屏障,增殖有益菌,增产抗炎短链脂肪酸
  • 抑制神经炎症:下调 IL-6 等炎症因子,调节 HPA 轴稳定情绪

MILESTONES

K0386专项成果

2017

(1)一株植物乳植杆菌体外抗氧化和耐药性的研究

(2)植物乳植杆菌 KLDS1.0386 对 C57BL/6 小鼠胆固醇代谢的影响

2019

(1)植物乳植杆菌 KLDS1.0386 联合色氨酸对溃疡性结肠炎的影响

(2)具有抑制 HT-29 细胞增殖及益生功能乳酸杆菌的筛选

2020

(1)Protective effects of tryptophan-catabolizing Lactobacillus plantarum KLDS 1.0386 against dextran sodium sulfate-induced colitis in mice

(2)Probiotic Mixture of Lactobacillus plantarum Strains Improves Lipid Metabolism and Gut Microbiota Structure in High Fat Diet‑Fed Mice

2021

(1)Proteolytic activities of combined fermentation with Lactobacillus helveticus KLDS 1.8701 and Lactobacillus plantarum  KLDS 1.0386 reduce antigenic response to cow milk proteins

2022

(1)Lactobacillus plantarum KLDS1.0386 with antioxidant capacity ameliorates the lipopolysaccharide-induced acute  liver injury in mice by NF-κB and Nrf2 pathway

(2)Immunomodulatory effects of mixed Lactobacillus plantarum on lipopolysaccharide‑induced intestinal injury in mice

(3)Cofermented cow milk protein by Lactobacillus helveticus KLDS 1.8701 and Lactobacillus plantarum KLDS 1.0386 attenuates its allergic immune response in Balb/c mice

2023

(1)胆盐水解酶基因在植物乳植杆菌KLDS1.0386 中的表达研究

2024

(1)联合体内外实验初步探究混合植物乳植杆菌的免疫调节能力

(2)TFS‑FENet: A time–frequency spatial deep learning framework for EEG‑based ADHD subtype classification

(3)Milk‑derived Lactobacillus with high production of short‑chain fatty acids relieves antibiotic‑induced diarrhea in mice

2025

(1)Lactiplantibacillus plantarum KLDS 1.0386 alleviates depression in CUMS mice based on tryptophan metabolic pathway

(2)Oral delivery of probiotic combined natural phenolic‑metal framework with microencapsulation for prolonged intestinal retention and alleviation of inflammatory bowel disease

(3)Preparation of polyvinyl alcohol/pullulan nanofibers and Eudragit® S100/ polyvinyl alcohol/pullulan core‑shell nanofibers for enhanced probiotic storage and oral viability

(4)Brain functional differences among ADHD subtypes in children revealed by phase‑amplitude coupling analysis of resting‑state EEG

2026

(1)胆盐水解酶基因在植物乳植杆菌KLDS1.0386 中的表达研究

(2)Dynamic Reconfiguration of Resting‑State Functional Brain Networks in ADHD: A Markov Chain Analysis of Source‑Space Synchronization States

(3)Identification of Children with ADHD Based on EEG Complexity and Cross‑Frequency Coupling Features

(4)Subtype‑Specific Causal Brain Network Mechanisms in ADHD Using Directed Visibility Graphs

K0386  专利益生菌

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